Neurological manifestations in Wiskott–Aldrich syndrome: a systematic review - Takeaways - MDSpire

Neurological manifestations in Wiskott–Aldrich syndrome: a systematic review

  • By

  • Nicholas Giulio Raccagni

  • Viktor Franco Milanesi

  • Giovanna Lucchini

  • Adriana Balduzzi

  • Giuseppe Occhino

  • Pietro Invernizzi

  • Serena Gasperini

  • May 7, 2026

  • 0 min

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  • 1

    Wiskott–Aldrich syndrome (WAS) is an X-linked immunodeficiency caused by mutations in the WAS gene, leading to significant morbidity and mortality.

  • 2

    Neurological manifestations in WAS include brain hemorrhagic, immune-mediated, infectious, and neoplastic incidents, with varying ages of onset.

  • 3

    Case-fatality rates for neurological events in WAS are notably high, particularly in infectious (100%) and neoplastic (75%) cases.

  • 4

    A majority of individuals studied were pediatric, with neurological symptoms emerging a median of 3 years after WAS diagnosis.

  • 5

    The review emphasizes the need for increased neurological awareness and systematic documentation in patients with WAS.

Original Source(s)

Neurological manifestations in Wiskott–Aldrich syndrome: a systematic review

  • by Nicholas Giulio Raccagni, Viktor Franco Milanesi, Giovanna Lucchini, Adriana Balduzzi, Giuseppe Occhino, Pietro Invernizzi, Serena Gasperini

  • May 7, 2026

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