Distinct Immunometabolic Alterations in Psoriasis and Atopic Dermatitis: Insights into Two Inflammatory Skin Conditions

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Psoriasis and atopic dermatitis are the two most common chronic inflammatory skin diseases, with distinct immunological profiles.
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Psoriasis is characterized by excessive epidermal proliferation and a Th17-dominant immune response, while AD features impaired skin barrier and a Th2-dominant profile.
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Metabolic pathways in immune cells are crucial for cellular differentiation and effector functions, influencing the pathology of both psoriasis and AD.
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Psoriasis exhibits upregulated glycolysis and abnormal cholesterol metabolism, whereas AD shows defects in ceramide synthesis and fatty acid metabolism.
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The article reviews the therapeutic potential of metabolism-targeted drugs, highlighting differences in treatment approaches for psoriasis and AD.

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