Fibrotic remodeling in the NOD/ShiLtJ mouse model of Sjögren’s disease: insights from single-cell transcriptomics and AI-driven ECM quantification - Takeaways - MDSpire

Exploring Fibrotic Changes in the NOD/ShiLtJ Mouse Model of Sjögren’s Disease: Insights from Single-Cell Transcriptomics and AI-Enhanced ECM Analysis

  • By

  • Jennifer M. Morrissey

  • Deirdre A. Nelson

  • Li Chen

  • Mathieu Petitjean

  • Joey R. Tavarez

  • Amber L. Altrieth-Flagg

  • Nicholas L. Moskwa

  • Renae Williams-Atkinson

  • Ben Fowler

  • Rafael Pena

  • Kennedi Weston

  • Nikhita Kumar

  • Nathan Aist

  • Melinda Larsen

  • July 20, 2026

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  • 1

    Sjögren's Disease is an autoimmune disorder leading to salivary gland hypofunction and lymphocytic infiltration, with unclear fibrosis contributions.

  • 2

    The NOD/ShiLtJ mouse model was used to study salivary gland fibrosis and the effects of antifibrotic therapy with nintedanib.

  • 3

    Single-cell RNA sequencing showed increased ECM gene expression in fibroblast populations of NOD/ShiLtJ mice compared to controls.

  • 4

    Picrosirius Red staining and AI-assisted quantification revealed significant fibrotic remodeling in the salivary glands of NOD/ShiLtJ mice.

  • 5

    Nintedanib treatment for 8 weeks resulted in modest reductions in multiple fibrotic indices in the NOD/ShiLtJ mouse model.

Original Source(s)

Fibrotic remodeling in the NOD/ShiLtJ mouse model of Sjögren’s disease: insights from single-cell transcriptomics and AI-driven ECM quantification

  • by Jennifer M. Morrissey, Deirdre A. Nelson, Li Chen, Mathieu Petitjean, Joey R. Tavarez, Amber L. Altrieth-Flagg, Nicholas L. Moskwa, Renae Williams-Atkinson, Ben Fowler, Rafael Pena, Kennedi Weston, Nikhita Kumar, Nathan Aist, Melinda Larsen

  • July 20, 2026

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