Ferroptosis in chemotherapy resistance and resensitization in breast cancer: a systematic review of preclinical evidence and translational implications

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Ferroptosis is an iron-dependent regulated cell death mechanism that may help overcome chemotherapy resistance in breast cancer.
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Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancers and is characterized by high aggressiveness and poor treatment outcomes.
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The GPX4 axis, iron metabolism regulation, and SLC7A11/xCT pathway are identified as the most consistently supported mechanisms of ferroptosis.
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Forty-four studies were included in the review, with the majority published since 2024, focusing primarily on TNBC.
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Methodological quality of the studies was adequate, but improvements are needed in randomization and blinding reporting in animal studies.

Frontiers In Oncology

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