HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee

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HLA compatibility is crucial for successful allogeneic hematopoietic cell transplantation (HCT), impacting survival rates significantly.
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Recent advances in typing technologies and GvHD prophylaxes have prompted a reevaluation of the relevance of HLA mismatches in contemporary HCT.
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The EBMT expert panel developed consensus recommendations addressing HLA typing, donor selection, and management of anti-HLA antibodies.
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Non-HLA factors, such as donor age, play a significant role in donor selection strategies alongside HLA matching.
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The frequency of HLA-mismatched transplants has increased, necessitating ongoing research to understand their impact on HCT outcomes.

Bone Marrow Transplantation

by Esteban Arrieta-Bolaños, Alberto Cardoso Martins Lima, Marco Andreani, Dianne De Santis, Florent Malard, Neema P. Mayor, Rohtesh S. Mehta, Roland Meisel, Simona Pagliuca, Effie Petersdorf, Simona Piemontese, Nicoletta Sacchi, Nicole Santoro, Jaime Sanz, Johannes Schetelig, Stephen R. Spellman, Francesco Onida, Isabel Sánchez-Ortega, Mohamad Mohty, Ibrahim Yakoub-Agha, Katharina Fleischhauer, Annalisa Ruggeri
June 2, 2026

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