TSC-associated microglial hyperactivity: enhanced calcium signaling, metabolism, and phagocytosis - Takeaways - MDSpire

TSC-associated microglial hyperactivity: enhanced calcium signaling, metabolism, and phagocytosis

  • By

  • Rozemarijn S. Kalf

  • Mark J. Luinenburg

  • Giulia Dematteis

  • Mirte Scheper

  • Jasper J. Anink

  • Giulia Cavallo

  • Andrea Mattarei

  • Wim Van Hecke

  • Angelika Mühlebner

  • Laura Tapella

  • James D. Mills

  • Dmitry Lim

  • Eleonora Aronica

  • February 13, 2026

  • 0 min

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  • 1

    Tuberous sclerosis complex (TSC) is a genetic disorder leading to benign tumors and neuropsychiatric disorders, primarily affecting the brain.

  • 2

    Microglial activation in TSC is linked to epilepsy and cognitive deficits, with chronic immune dysregulation contributing to these issues.

  • 3

    Dysregulated calcium signaling in microglia is hypothesized to be a significant factor in TSC pathophysiology, influenced by mTOR hyperactivation.

  • 4

    TSC-derived microglia-like cells exhibit increased metabolic activity, altered inflammatory responses, and enhanced phagocytic function.

  • 5

    Single-cell RNA sequencing revealed evidence of calcium dysregulation and a hyperresponsive microglial state in TSC brain tissue.

Original Source(s)

TSC-associated microglial hyperactivity: enhanced calcium signaling, metabolism, and phagocytosis

  • by Rozemarijn S. Kalf, Mark J. Luinenburg, Giulia Dematteis, Mirte Scheper, Jasper J. Anink, Giulia Cavallo, Andrea Mattarei, Wim Van Hecke, Angelika Mühlebner, Laura Tapella, James D. Mills, Dmitry Lim, Eleonora Aronica

  • February 13, 2026

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