CD32b defines distinct dendritic cell lineages generated from the culture of bone marrow with GM-CSF

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GM-CSF cultures generate mouse dendritic cells (DCs) from bone marrow, comprising two distinct subsets based on CD32b expression.
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CD32b- GM-DCs arise from monocyte-dendritic cell progenitors (MDPs) within the first week of culture.
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CD32b+ GM-DCs are generated by granulocyte-monocyte progenitors (GMPs) at a slower rate and dominate in later culture stages.
4

Distinct pre-GM-DC populations exist in culture, characterized by different surface markers and functions.
5

CD32b+ GM-DCs have a greater capacity to stimulate CD4+ T cells compared to CD32b- GM-DCs.

Frontiers In Immunology

by Wanho Choi, Seul Hye Ryu, Ji Soo Park, Da Eun Park, Min Kyung Chu, Hye Young Na, Chae Gyu Park
May 29, 2026

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