Novel approaches for separating graft-versus-leukemia effects from graft-versus-host disease

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Allogeneic hematopoietic cell transplantation is a curative therapy for hematologic malignancies but poses challenges in separating GVL effects from GVHD.
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Post-transplant relapse is driven by mechanisms such as immune escape, T-cell exhaustion, and persistence of leukemia stem cells.
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Emerging strategies aim to enhance tissue tolerance and selectively modulate T-cell trafficking to reduce GVHD while preserving GVL effects.
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Restoration of leukemia immunogenicity and targeted elimination of leukemia stem cells may prevent relapse without worsening GVHD.
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Recent advances in immune profiling techniques have accelerated research into the mechanisms of post-transplant relapse and GVHD pathophysiology.

Frontiers In Oncology

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