Precision identification and targeted therapy for neutrophilic asthma: from molecular mechanisms to clinical translation - Takeaways - MDSpire

Precision identification and targeted therapy for neutrophilic asthma: from molecular mechanisms to clinical translation

  • By

  • Mengmeng Sun

  • Yan Xu

  • Guihua Song

  • Bingxue Zhang

  • MingHao Peng

  • SuPing Yu

  • GuiChun Zhang

  • July 8, 2026

  • 0 min

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  • 1

    Neutrophilic asthma is characterized by sputum neutrophilia, glucocorticoid resistance, and a more severe disease course compared to eosinophilic asthma.

  • 2

    The Th17/IL-17 axis plays a central role in neutrophilic asthma pathogenesis, driving neutrophil recruitment and activation.

  • 3

    Neutrophilic asthma exhibits intrinsic resistance to glucocorticoids due to impaired neutrophil apoptosis and persistent pro-inflammatory pathways.

  • 4

    Emerging therapeutic approaches targeting IL-17, NET formation, and inflammasome components are currently in clinical development.

  • 5

    Airway microbiome dysbiosis is implicated in neutrophilic asthma, suggesting novel therapeutic targets related to neutrophilic inflammation.

Original Source(s)

Precision identification and targeted therapy for neutrophilic asthma: from molecular mechanisms to clinical translation

  • by Mengmeng Sun, Yan Xu, Guihua Song, Bingxue Zhang, MingHao Peng, SuPing Yu, GuiChun Zhang

  • July 8, 2026

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