Esculentoside A mitigates oxidative stress and neuronal apoptosis in spinal cord injury by modulating the Nrf2/HO-1 pathway - Takeaways - MDSpire

Esculentoside A mitigates oxidative stress and neuronal apoptosis in spinal cord injury by modulating the Nrf2/HO-1 pathway

  • By

  • Guoqing Zhu

  • Weiwei Li

  • Mengge Sun

  • Jingyu Yan

  • Wei Hu

  • June 24, 2026

  • 0 min

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  • 1

    Esculentoside A (EsA) is a bioactive saponin from Phytolaca esculenta that exhibits neuroprotective potential in spinal cord injury (SCI) models.

  • 2

    EsA treatment significantly improved motor function and reduced histopathological damage in rats with SCI.

  • 3

    The neuroprotective effects of EsA were associated with reduced oxidative stress and neuronal apoptosis in the injured spinal cord.

  • 4

    EsA activated the Nrf2/HO-1 signaling pathway, which plays a crucial role in modulating oxidative stress and protecting neurons.

  • 5

    The study suggests that EsA may serve as a therapeutic agent for spinal cord injury by targeting oxidative damage and neuronal loss.

Original Source(s)

Esculentoside A mitigates oxidative stress and neuronal apoptosis in spinal cord injury by modulating the Nrf2/HO-1 pathway

  • by Guoqing Zhu, Weiwei Li, Mengge Sun, Jingyu Yan, Wei Hu

  • June 24, 2026

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