Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study - Takeaways - MDSpire

Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study

  • By

  • Mónica M. Velásquez-Esparza

  • Perla Pérez-Treviño

  • Leticia Elizondo-Montemayor

  • Elena Cristina Castillo

  • Norma Cipatli Ayuzo Del Valle

  • Noemí García

  • June 29, 2026

  • 0 min

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  • 1

    Childhood obesity is linked to cardiometabolic dysfunction, with oxidative stress and mitochondrial damage playing potential roles.

  • 2

    The study evaluated oxidative DNA damage and circulating mitochondrial DNA integrity in children with varying obesity phenotypes.

  • 3

    Both preclinical and clinical obesity groups exhibited higher oxidative DNA damage and reduced mitochondrial DNA integrity compared to controls.

  • 4

    Oxidative DNA damage correlated positively with triglyceride levels and inversely with circulating mitochondrial DNA integrity.

  • 5

    Elevated cytokine concentrations were observed in children with preclinical and clinical obesity compared to normal-weight controls.

Original Source(s)

Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study

  • by Mónica M. Velásquez-Esparza, Perla Pérez-Treviño, Leticia Elizondo-Montemayor, Elena Cristina Castillo, Norma Cipatli Ayuzo Del Valle, Noemí García

  • June 29, 2026

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