Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients - Takeaways - MDSpire

Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients

  • By

  • Joris Holtrop

  • Mari Nordbø Gynnild

  • Toril Dammen

  • Håvard Dalen

  • Ingvild Saltvedt

  • Hanne Ellekjær

  • Steven H J Hageman

  • Frank L J Visseren

  • John William McEvoy

  • Jannick A N Dorresteijn

  • John Munkhaugen

  • On behalf of the UCC-SMART study group

  • August 26, 2025

  • 0 min

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  • 1

    Psychological factors like depression, anxiety, and insomnia are prevalent in patients with atherosclerotic cardiovascular disease.

  • 2

    The SMART2 model reliably estimates the 10-year risk of recurrent cardiovascular events, even in patients with psychological conditions.

  • 3

    Integrating psychological factors into the SMART2 model showed minimal added predictive value for estimating cardiovascular risk.

  • 4

    In a study of 20,050 patients, psychological factors did not significantly improve the prediction of recurrent cardiovascular events.

  • 5

    The findings suggest that psychological factors may contribute to undertreatment but do not enhance risk assessment in cardiovascular disease.

Original Source(s)

Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients

  • by Joris Holtrop, Mari Nordbø Gynnild, Toril Dammen, Håvard Dalen, Ingvild Saltvedt, Hanne Ellekjær, Steven H J Hageman, Frank L J Visseren, John William McEvoy, Jannick A N Dorresteijn, John Munkhaugen, On behalf of the UCC-SMART study group

  • August 26, 2025

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