Case Report: A rare case of over 45 years’ survival in a patient with tonsillar adenoid cystic carcinoma - Takeaways - MDSpire

Case Report: A rare case of over 45 years’ survival in a patient with tonsillar adenoid cystic carcinoma

  • By

  • Mingzhu Wang

  • Tingyao Ma

  • Yue Zhao

  • Shujing Zhang

  • Xuelian Wang

  • Guoliang Yang

  • Xi Zhao

  • Yixuan Liu

  • Tian Ye

  • Mengmeng Li

  • Jun Wu

  • Lanlan Xuan

  • Xiaohong Chen

  • Zheng Yang

  • June 2, 2026

  • 0 min

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  • 1

    Tonsillar adenoid cystic carcinoma (TACC) is a rare malignancy with a long disease trajectory and unpredictable clinical behavior.

  • 2

    The patient, diagnosed in 1977, experienced a prolonged indolent phase lasting over 40 years before rapid disease progression.

  • 3

    Molecular profiling of the recurrent lesion in 2018 revealed NOTCH2 copy number gain and structural variants in MTOR and SPEN.

  • 4

    The patient underwent multiple treatments, including tonsillectomy, radiotherapy, and radical resection, throughout her disease course.

  • 5

    The patient died in 2024 due to complications from progressive intracranial and systemic metastases.

Original Source(s)

Case Report: A rare case of over 45 years’ survival in a patient with tonsillar adenoid cystic carcinoma

  • by Mingzhu Wang, Tingyao Ma, Yue Zhao, Shujing Zhang, Xuelian Wang, Guoliang Yang, Xi Zhao, Yixuan Liu, Tian Ye, Mengmeng Li, Jun Wu, Lanlan Xuan, Xiaohong Chen, Zheng Yang

  • June 2, 2026

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