Calibrated ensemble deep learning for four-class lung CT image classification and uncertainty-based referral - Takeaways - MDSpire
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Uncertainty-Guided Referral Using Calibrated Deep-Learning Ensembles for Four-Class Lung CT Classification

  • By

  • Mohammad Fathi

  • Mohammad Reza Gholami

  • Nima Alipour

  • Mahshad Faramarzi

  • Niloofar Deravi

  • Danyal Yarahmadi

  • October 9, 2026

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  • 1

    The study developed and internally evaluated an architecture-diverse deep-learning ensemble to classify CT images as adenocarcinoma, large cell carcinoma, squamous cell carcinoma, or normal lung.

  • 2

    The analysis assessed validation-based model selection, weighted ensembling, temperature scaling, class-specific decision scaling, calibration, class-specific errors, and predictive entropy.

  • 3

    The intended use was assistive classification and uncertainty-informed prioritization for expert review, not replacement of histopathology, molecular testing, or radiologist interpretation.

  • 4

    The publicly available dataset contained 1,000 images labeled in four categories, and the repository labels served as the operational reference standard.

  • 5

    The dataset's original diagnostic verification methods and patient-level independence between partitions could not be determined.

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