VCAM1 from Glial Cells Enhances the Advancement of Gliomas - Takeaways - MDSpire

VCAM1 from Glial Cells Enhances the Advancement of Gliomas

  • By

  • Jiajing Dai

  • Hailong Zheng

  • Jiaxu Luo

  • Minlin Dai

  • Xiao-Ling Hu

  • Wenzhi Sun

  • April 24, 2026

  • 0 min

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  • 1

    VCAM1 is highly expressed in glioma stem cell-like cells, with significant co-expression in key proliferative markers such as SOX2 and CD133.

  • 2

    Selective deletion of VCAM1 in astrocytes significantly improved survival in glioma-bearing mice, extending median survival from 52 to 66.5 days.

  • 3

    Lower VCAM1 expression correlates with prolonged survival in low-grade glioma patients, indicating its potential as a prognostic marker.

  • 4

    Astrocyte-derived VCAM1 plays a critical role in glioma progression by mediating interactions between tumor cells and the tumor microenvironment.

  • 5

    Targeting VCAM1 signaling may offer a promising therapeutic strategy for gliomas, but its effectiveness may vary based on tumor location and genetics.

Original Source(s)

VCAM1 from Glial Cells Enhances the Advancement of Gliomas

  • by Jiajing Dai, Hailong Zheng, Jiaxu Luo, Minlin Dai, Xiao-Ling Hu, Wenzhi Sun

  • April 24, 2026

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