An atypical immunophenotype in generalized eruptive histiocytosis: a case report of coexisting scattered S-100 positivity and seropositivity for Anti-nRNP/Sm antibodies - Takeaways - MDSpire
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Uncommon Immunophenotypic Features in Generalized Eruptive Histiocytosis: A Case Study Highlighting Scattered S-100 Positivity and Anti-nRNP/Sm Antibody Seropositivity

  • By

  • Xinran Du

  • Siyu Pu

  • Ruizheng Zhu

  • Dongjie Guo

  • August 18, 2026

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  • 1

    Generalized eruptive histiocytosis (GEH) is a rare non-Langerhans cell histiocytosis characterized by multiple symmetrical papular lesions.

  • 2

    The case study presents a 60-year-old male with scattered S-100 positivity and positive anti-nRNP/Sm antibodies, indicating atypical immunophenotypic features.

  • 3

    Histopathological examination revealed significant infiltration of histiocytes, plasma cells, and eosinophils in the upper to mid-dermis.

  • 4

    Immunohistochemical analysis showed diffuse positivity for CD68 and negativity for CD1a, with scattered S-100 positivity noted.

  • 5

    The presence of anti-nRNP/Sm antibodies suggests a potential link between localized histiocytic activation and systemic immune dysregulation.

Original Source(s)

An atypical immunophenotype in generalized eruptive histiocytosis: a case report of coexisting scattered S-100 positivity and seropositivity for Anti-nRNP/Sm antibodies

  • by Xinran Du, Siyu Pu, Ruizheng Zhu, Dongjie Guo

  • August 18, 2026

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