Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination - Takeaways - MDSpire

Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination

  • By

  • Ayako Sedohara

  • Yoshiaki Kanno

  • Keiko Arai

  • Kotaro Arizono

  • Michiko Koga

  • Fumio Nakahara

  • Makoto Saito

  • Eisuke Adachi

  • Hiroshi Yotsuyanagi

  • March 11, 2026

  • 0 min

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  • 1

    HIV infection leads to chronic inflammation and complications, despite improvements in prognosis from antiretroviral therapy.

  • 2

    T follicular helper (Tfh) cells are crucial for B cell differentiation and antibody production in secondary lymphoid tissues.

  • 3

    A significant percentage of HIV-positive individuals do not acquire antibodies after hepatitis B vaccination, impacting their immune response.

  • 4

    The study found that HIV-positive individuals who are HBsAb-negative have lower circulating Tfh cells compared to those who are HBsAb-positive.

  • 5

    This research highlights the need to understand the impact of HIV on circulating Tfh cells to improve vaccination outcomes in HIV-positive populations.

Original Source(s)

Impairment of Circulating Follicular Helper T Cells in HIV-Positive Individuals Who Are Negative for Hepatitis B Surface Antibody Despite Vaccination

  • by Ayako Sedohara, Yoshiaki Kanno, Keiko Arai, Kotaro Arizono, Michiko Koga, Fumio Nakahara, Makoto Saito, Eisuke Adachi, Hiroshi Yotsuyanagi

  • March 11, 2026

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