Physician- and Practice-Level Variation in Clinical Trial Participation Among Patients With Advanced Cancer - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Variability in Clinical Trial Enrollment for Patients with Advanced Cancer at the Physician and Practice Levels

  • By

  • Changchuan Jiang

  • Chuan Angel Lu

  • Joshua M. Liao

  • Ryan D. Nipp

  • K. Robin Yabroff

  • Helen H. Moon

  • Song Zhang

  • Xin Hu

  • Tian Zhang

  • October 6, 2026

Share

  • 1

    Clinical trial enrollment for patients with advanced cancer remains below 10%, despite most patients expressing willingness to participate.

  • 2

    The study identifies that the primary bottleneck for trial enrollment lies within the clinical delivery architecture, not patient-level obstacles.

  • 3

    Variation in trial participation is influenced by physician referral practices and the infrastructure of oncology practices.

  • 4

    The analysis utilized a national cohort of over 200,000 patients from the Flatiron Health Research Database to assess trial participation.

  • 5

    Disparities in clinical trial access based on race and ethnicity were acknowledged, with data collected through patient self-report and clinician documentation.

Original Source(s)

Physician- and Practice-Level Variation in Clinical Trial Participation Among Patients With Advanced Cancer

  • by Changchuan Jiang, Chuan Angel Lu, Joshua M. Liao, Ryan D. Nipp, K. Robin Yabroff, Helen H. Moon, Song Zhang, Xin Hu, Tian Zhang

  • October 6, 2026

Related Content

Personalized Cancer Vaccine Linked to Three-Year Disease-Free Survival in Head and Neck Cancer

All 16 patients who received TG4050 after standard treatment remained disease-free, compared with 13 of 16 patients in the control group

  • September 16, 2026

  • 2 min
Posterior fossa ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes (Part I of ependymomas across compartments)

Spinal ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes with a focus on the pediatric population (Part III of ependymomas across compartments)