C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders - Takeaways - MDSpire

C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders

  • By

  • Chenxu Zhao

  • Elnaz Naderi

  • Tesfa Dejenie Habtewold

  • Therese van Amelsvoort

  • Wiepke Cahn

  • Lieuwe de Haan

  • Marieke van der Pluijm

  • Claudia J.P. Simons

  • Jim van Os

  • Wim Veling

  • Richard Bruggeman

  • Behrooz Z. Alizadeh

  • July 14, 2026

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  • 1

    Patients with schizophrenia spectrum disorders (SSDs) have a higher risk of cardiometabolic dysregulations impacting cardiovascular health.

  • 2

    The study examined the association of polygenic risk scores for C-reactive protein (CRP) and interleukin 6 (IL-6) with cardiometabolic outcomes in SSDs.

  • 3

    Higher standardized PRSCRP was significantly associated with increased body mass index (BMI) and waist circumference (WC) in SSD patients.

  • 4

    Nominal associations were found between PRSCRP and triglyceride levels, as well as metabolic composite scores, but did not remain significant after correction.

  • 5

    The findings suggest that genetic susceptibility to low-grade inflammation may contribute to obesity-related traits in SSDs, independent of antipsychotic use.

Original Source(s)

C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders

  • by Chenxu Zhao, Elnaz Naderi, Tesfa Dejenie Habtewold, Therese van Amelsvoort, Wiepke Cahn, Lieuwe de Haan, Marieke van der Pluijm, Claudia J.P. Simons, Jim van Os, Wim Veling, Richard Bruggeman, Behrooz Z. Alizadeh

  • July 14, 2026

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