Imaging Leukocyte Dynamics in Retinal Disease - Takeaways - MDSpire

Imaging Leukocyte Dynamics in Retinal Disease

The movement of immune cells through the retinal vasculature has long been inferred from laboratory models. Now, advances in imaging are allowing clinicians to observe these processes directly. At the 2026 meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Denver, Richard B. Rosen, MD, ScD(hon), FACS, FASRS, FARVO, described early clinical work using adaptive optics scanning laser ophthalmoscopy (AOSLO) to visualize leukocyte trafficking in vivo.

  • By

  • Jim Gallagher, senior managing editor

  • May 1, 2026

  • 4 min

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  • 1

    Richard B. Rosen, MD, presented in vivo AOSLO imaging of leukocyte trafficking in retinal disease at ARVO 2026.

  • 2

    AOSLO enables high-resolution imaging of retinal microvasculature, allowing direct observation of leukocyte dynamics.

  • 3

    Leukocyte activity was more frequently observed in venules than arterioles, with a 10:1 difference in movement.

  • 4

    Distinct leukocyte behaviors were noted in various diseases, including stalling in diabetic retinopathy and increased activity in uveitis.

  • 5

    Visualizing leukocyte dynamics in vivo may enhance understanding of disease mechanisms and inform therapeutic strategies.

Original Source(s)

Imaging Leukocyte Dynamics in Retinal Disease

  • by Jim Gallagher, senior managing editor

  • May 1, 2026

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