Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study - Takeaways - MDSpire

Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study

  • By

  • Jihwan Yoo

  • Hun Ho Park

  • Seo Yeon Kim

  • Sung Jun Ahn

  • Jungho Ahn

  • Jiwoong Oh

  • Jaejoon Lim

  • May 21, 2026

  • 0 min

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  • 1

    The study analyzed 117 breast cancer patients with brain metastases to assess the impact of monocyte-related ratios on survival outcomes.

  • 2

    Absolute monocyte count increased 2.11-fold at brain metastasis diagnosis compared to initial breast cancer diagnosis.

  • 3

    Patients in the high lymphocyte-to-monocyte ratio group had a median survival of 20.0 months, significantly longer than the low group at 5.13 months.

  • 4

    Triple-negative breast cancer subtype, low lymphocyte-to-monocyte ratio, and number of brain metastases were linked to poorer survival.

  • 5

    The findings suggest that monocyte dynamics may serve as potential prognostic markers for breast cancer patients with brain metastases.

Original Source(s)

Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study

  • by Jihwan Yoo, Hun Ho Park, Seo Yeon Kim, Sung Jun Ahn, Jungho Ahn, Jiwoong Oh, Jaejoon Lim

  • May 21, 2026

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