Optimal timing for frozen-thawed embryo transfer: evidence from a systematic review and meta-analysis - Takeaways - MDSpire

Optimal timing for frozen-thawed embryo transfer: evidence from a systematic review and meta-analysis

  • By

  • Guangzhong Jiao

  • Huayu Lian

  • Xiaoyan Liu

  • Xunlan Yin

  • July 15, 2026

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  • 1

    The study evaluated the association between cryopreservation duration and reproductive/neonatal outcomes using a meta-analysis of 17 studies.

  • 2

    Shorter storage duration (≤12 months) correlated with higher live birth, biochemical pregnancy, and clinical pregnancy rates.

  • 3

    Substantial heterogeneity was observed in the results, with prediction intervals crossing the null line, indicating variability in outcomes.

  • 4

    Maternal age significantly influenced live birth and clinical pregnancy rates, while no significant differences were found in other outcomes.

  • 5

    The study concluded that storage duration should not solely dictate transfer timing, emphasizing individualized clinical decision-making.

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