Intestinal lactate as a crucial molecular for intestinal epithelial cell renewal in sepsis - Takeaways - MDSpire

Intestinal lactate as a crucial molecular for intestinal epithelial cell renewal in sepsis

  • By

  • Pan You

  • Xuepeng Zhang

  • Maoxia Liu

  • Qinyi Fu

  • Siyuan Chen

  • October 24, 2025

  • 0 min

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  • 1

    Sepsis is a leading cause of death in ICU patients, significantly affecting the gastrointestinal tract and causing acute gastrointestinal injury.

  • 2

    Lactate, previously viewed as a waste product, is essential for the proliferation of intestinal stem cells and enhances epithelial cell renewal.

  • 3

    In a sepsis model, lactate levels in the intestine decreased while serum lactate levels increased, indicating metabolic reprogramming.

  • 4

    Lactate administration in CLP mice improved survival trends and increased intestinal length and villus length compared to controls.

  • 5

    The study suggests that intestinal lactate may protect against sepsis-induced damage and could be a therapeutic strategy for critically ill patients.

Original Source(s)

Intestinal lactate as a crucial molecular for intestinal epithelial cell renewal in sepsis

  • by Pan You, Xuepeng Zhang, Maoxia Liu, Qinyi Fu, Siyuan Chen

  • October 24, 2025

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