Primary large cell neuroendocrine carcinoma of the breast with metastasis in the lymph nodes: a case report and literature review - Takeaways - MDSpire

Primary large cell neuroendocrine carcinoma of the breast with metastasis in the lymph nodes: a case report and literature review

  • By

  • HongYan Li

  • MaoTao He

  • HengMing Zhang

  • ChunYu Yu

  • MaiQing Yang

  • June 11, 2026

  • 0 min

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  • 1

    Primary large cell neuroendocrine carcinoma (LCNEC) of the breast is a rare subtype, accounting for less than 5% of all primary breast carcinomas.

  • 2

    A 47-year-old female was diagnosed with primary LCNEC of the breast after presenting with a left breast mass and lymph node metastasis.

  • 3

    The tumor exhibited a triple-negative immunophenotype, complicating its differentiation from conventional triple-negative breast cancer (TNBC).

  • 4

    Accurate diagnosis of breast LCNEC requires immunohistochemical assessment to distinguish it from other breast cancer subtypes.

  • 5

    The patient underwent neoadjuvant chemotherapy followed by modified radical mastectomy, with short-term follow-up indicating favorable disease control.

Original Source(s)

Primary large cell neuroendocrine carcinoma of the breast with metastasis in the lymph nodes: a case report and literature review

  • by HongYan Li, MaoTao He, HengMing Zhang, ChunYu Yu, MaiQing Yang

  • June 11, 2026

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