Successful rescue therapy with eculizumab for probable tislelizumab-related MMM overlap syndrome with dual positivity for anti-acetylcholine receptor and anti-titin antibodies: a case report and literature review

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Eculizumab was successfully used as a rescue treatment for a patient with tislelizumab-induced MMM overlap syndrome and dual seropositivity.
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The patient, a 64-year-old male, developed severe symptoms including ptosis and tetraparesis after receiving tislelizumab for lung adenocarcinoma.
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Conventional treatments like corticosteroids and IVIG were ineffective, leading to rapid clinical deterioration before eculizumab was administered.
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Eculizumab treatment resulted in rapid clinical improvement, achieving minimal symptom expression without exacerbation.
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This case highlights eculizumab's potential as an effective rescue option for ICI-MMM, warranting further prospective evaluation.

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