THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model - Takeaways - MDSpire

THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model

  • By

  • Dattatreyamurty Bosukonda

  • Romesh R. Subramanian

  • Peter C. Keck

  • Philippe Bey

  • Frederic R. Carlson

  • William D. Carlson

  • June 25, 2026

  • 0 min

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  • 1

    THR-123 is a BMP-7 mimetic that enhances Akt phosphorylation and reduces cardiomyocyte apoptosis and inflammation.

  • 2

    In a rat model, THR-123 significantly decreased myocardial infarct size by 84% and reduced pericardial inflammation.

  • 3

    The mechanism of action of THR-123 involves the activation of the PI3K/Akt pathway in cardiomyocytes.

  • 4

    THR-123 demonstrates anti-inflammatory, anti-apoptotic, and anti-fibrotic properties, promoting tissue regeneration.

  • 5

    The study suggests THR-123 may serve as a novel pharmacological intervention for myocardial injury.

Original Source(s)

THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model

  • by Dattatreyamurty Bosukonda, Romesh R. Subramanian, Peter C. Keck, Philippe Bey, Frederic R. Carlson, William D. Carlson

  • June 25, 2026

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