Strengthening surgical antibiotic stewardship in low-resource settings: a multicentre, prospective, quality improvement study - Takeaways - MDSpire

Strengthening surgical antibiotic stewardship in low-resource settings: a multicentre, prospective, quality improvement study

  • By

  • Clean Cut Investigators Group

  • John Ibyishaka

  • Yvonne Uwabagira

  • Mediatrice Cyuzuzo

  • Celine Tuyishime

  • Florentine Uwingabire

  • Pierre Celestin Ukobizaba

  • Jean Paul Niyigena

  • Jean Yves Shyrirakera

  • Marie Chantal Umurerwa

  • Gaudence Kabagwira

  • Vestine Musabende

  • Abraham Kwizera

  • Innocent Byamungu

  • Deborah Mukantibaziyaremye

  • Leontine Neema

  • Pierrine Nyirangeri

  • Valens Majyambere

  • Emmanuel Nsengimana

  • Andrew Oryono

  • Fabrice Habarugira

  • Valens Dusabimana

  • Diane Senga

  • Gerard Harerimana

  • Aloys Hakizimana

  • Yves Berard Niyomugabo

  • Senait Bitew Alemu

  • Sara Taye Hale

  • Barnabas Alayende

  • Maia R Nofal

  • Alype Rwamatwara

  • Roda Uwayesu

  • David Tuyisenge

  • Justin Bayisenga

  • Ronald Tubasiime

  • Febronie Muhorakeye

  • Assefa Tesfaye

  • Samantha Steeman

  • Hillena Kebede

  • Natnael Gebeyehu

  • Abebe Bekele

  • Tihitena Negussie Mammo

  • Thomas G Weiser

  • December 10, 2025

  • 0 min

Share

  • 1

    Surgical site infections (SSIs) are prevalent in low-income countries, exacerbated by overprescribing of antibiotic prophylaxis.

  • 2

    An integrated quality improvement program was implemented in Rwanda to reduce prolonged antibiotic prophylaxis and improve infection prevention.

  • 3

    The program resulted in a decrease in prolonged prophylaxis from 40.7% to 14.1% while improving compliance with infection prevention standards.

  • 4

    Early cessation of antibiotics did not increase SSI rates, with rates of 8.9% for early cessation compared to 17.2% for prolonged prophylaxis.

  • 5

    The findings support that strengthening infection prevention systems is essential for effective antimicrobial stewardship in resource-limited settings.

Original Source(s)

Strengthening surgical antibiotic stewardship in low-resource settings: a multicentre, prospective, quality improvement study

  • by Clean Cut Investigators Group, John Ibyishaka, Yvonne Uwabagira, Mediatrice Cyuzuzo, Celine Tuyishime, Florentine Uwingabire, Pierre Celestin Ukobizaba, Jean Paul Niyigena, Jean Yves Shyrirakera, Marie Chantal Umurerwa, Gaudence Kabagwira, Vestine Musabende, Abraham Kwizera, Innocent Byamungu, Deborah Mukantibaziyaremye, Leontine Neema, Pierrine Nyirangeri, Valens Majyambere, Emmanuel Nsengimana, Andrew Oryono, Fabrice Habarugira, Valens Dusabimana, Diane Senga, Gerard Harerimana, Aloys Hakizimana, Yves Berard Niyomugabo, Senait Bitew Alemu, Sara Taye Hale, Barnabas Alayende, Maia R Nofal, Alype Rwamatwara, Roda Uwayesu, David Tuyisenge, Justin Bayisenga, Ronald Tubasiime, Febronie Muhorakeye, Assefa Tesfaye, Samantha Steeman, Hillena Kebede, Natnael Gebeyehu, Abebe Bekele, Tihitena Negussie Mammo, Thomas G Weiser

  • December 10, 2025

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