Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus - Takeaways - MDSpire

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus

  • By

  • Nannan Lv

  • Jianjian Xiang

  • Jinsong Kuang

  • Fei Liu

  • Lan Cheng

  • Shanyu Yin

  • June 4, 2026

  • 0 min

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  • 1

    25-hydroxyvitamin D deficiency is prevalent in 83.7% of patients with type 2 diabetes mellitus, impacting calcium metabolism and inflammation.

  • 2

    Higher serum 25(OH)D levels correlate with lower parathyroid hormone and higher calcium levels, indicating altered calcium-PTH homeostasis.

  • 3

    Moderate deficiency of 25(OH)D is associated with peak high-sensitivity C-reactive protein levels, suggesting increased inflammation.

  • 4

    Thyroid autoantibody positivity shows opposing relationships with 25(OH)D levels, indicating complex interactions in thyroid autoimmunity.

  • 5

    The study highlights the need for integrated evaluations of vitamin D status, calcium regulation, and inflammation in T2DM patients.

Original Source(s)

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus

  • by Nannan Lv, Jianjian Xiang, Jinsong Kuang, Fei Liu, Lan Cheng, Shanyu Yin

  • June 4, 2026

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