Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis - Takeaways - MDSpire

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • By

  • Yarui Huang

  • Qingrong Li

  • Xin Xu

  • Ju Li

  • Yan Zhu

  • Chengxin Luo

  • Jiegang Xu

  • Jiaming Liu

  • Jianmin Zhang

  • Ping Wang

  • Ya Tan

  • Yaqun Ding

  • Shuangnian Xu

  • Run Chen

  • Ling Wei

  • July 14, 2026

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  • 1

    The systematic review evaluated the impact of donor KIR haplotypes on survival outcomes in allogeneic hematopoietic stem cell transplantation.

  • 2

    Seventeen studies were included, revealing that donor KIR B/X genotype significantly improves overall survival and reduces relapse incidence.

  • 3

    The meta-analysis showed a pooled hazard ratio of 0.68 for overall survival associated with donor KIR B/X genotype.

  • 4

    Donor KIR B/X haplotype was linked to improved relapse-free survival with a hazard ratio of 0.61.

  • 5

    The findings support the potential use of donor KIR haplotypes as a biomarker for optimizing donor selection in allo-HSCT.

Original Source(s)

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • by Yarui Huang, Qingrong Li, Xin Xu, Ju Li, Yan Zhu, Chengxin Luo, Jiegang Xu, Jiaming Liu, Jianmin Zhang, Ping Wang, Ya Tan, Yaqun Ding, Shuangnian Xu, Run Chen, Ling Wei

  • July 14, 2026

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