Plerixafor is superior to conventional chemotherapy for first-line stem cell mobilisation, and is effective even in heavily pretreated patients

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Plerixafor combined with G-CSF significantly improves stem cell yields compared to G-CSF alone in lymphoma and myeloma patients.
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In the PHANTASTIC study, plerixafor+G-CSF resulted in better CD34+ cell yields and reduced toxicity compared to conventional chemotherapy.
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The combination of plerixafor and G-CSF allows for successful stem cell mobilization in patients who fail to mobilize adequately with chemotherapy.
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No differences were observed in engraftment times or clinical outcomes between patients treated with plerixafor+G-CSF and those receiving chemotherapy.
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Plerixafor+G-CSF is recommended as a first-line stem cell mobilization strategy over chemotherapy+G-CSF for autologous stem cell transplantation.

Blood Cancer Journal

by R E Clark, J Bell, J O Clark, B Braithwaite, U Vithanarachchi, N McGinnity, T Callaghan, S Francis, R Salim
October 31, 2014

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