Diabetes Risk Scores: Beyond Glucose

Multi-ancestry polygenic models identify high-risk patients traditional screening may miss.

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Multi-ancestry polygenic risk scores (PRSs) significantly enhance type 2 diabetes risk stratification across diverse ancestry groups.
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The study analyzed data from 409,959 participants with type 2 diabetes and nearly 2 million controls, validating PRSs in multiple cohorts.
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Multi-ancestry PRSs showed larger effect sizes than single-ancestry PRSs, with odds of type 2 diabetes varying significantly by ancestry.
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Higher PRS values were linked to increased odds of diabetes-related complications, including diabetic retinopathy and nephropathy.
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The study highlights limitations in current PRS models and emphasizes the need for ongoing trials to assess their clinical implementation.

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