Primary diffuse large b-cell lymphoma of the lip: a case report and literature review - Takeaways - MDSpire

Primary diffuse large b-cell lymphoma of the lip: a case report and literature review

  • By

  • Pingping Liu

  • Changjiang Xu

  • Liming Yu

  • Xiuying Wang

  • Yan Wang

  • Xiaofei Yan

  • June 8, 2026

  • 0 min

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  • 1

    Primary diffuse large B-cell lymphoma (DLBCL) of the lip is a rare subtype of extranodal non-Hodgkin lymphoma, comprising less than 1% of cases.

  • 2

    A 65-year-old male presented with upper lip swelling initially misdiagnosed as a maxillary space infection, highlighting diagnostic challenges.

  • 3

    Imaging studies revealed a poorly defined mass, and biopsy confirmed the diagnosis of germinal center B-cell (GCB) subtype DLBCL.

  • 4

    The patient was treated successfully with six cycles of R-CHOP chemotherapy and achieved complete metabolic remission.

  • 5

    This case underscores the need for a high index of suspicion for malignancy in persistent lip lesions and the importance of multidisciplinary care.

Original Source(s)

Primary diffuse large b-cell lymphoma of the lip: a case report and literature review

  • by Pingping Liu, Changjiang Xu, Liming Yu, Xiuying Wang, Yan Wang, Xiaofei Yan

  • June 8, 2026

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