Cholinergic degeneration in prodromal and early Parkinson’s disease: a link to present and future disease states - Takeaways - MDSpire

Cholinergic degeneration in prodromal and early Parkinson’s disease: a link to present and future disease states

  • By

  • Tamir Eisenstein

  • Karolien Groenewald

  • Ludo van Hillegondsberg

  • Falah Al Hajraf

  • Tanja Zerenner

  • Michael A Lawton

  • Yoav Ben-Shlomo

  • Ludovica Griffanti

  • Michele T Hu

  • Johannes C Klein

  • May 6, 2025

  • 0 min

Share

  • 1

    Cholinergic system degeneration in Parkinson's disease (PD) affects cognitive function and disease progression beyond dopaminergic loss.

  • 2

    Lower grey matter volume in the nucleus basalis of Meynert (NbM) is observed in early PD and isolated REM sleep behavior disorder (iRBD) patients.

  • 3

    Higher NbM volume correlates with better cognitive function and lower symptom burden in PD, indicating its potential as a biomarker.

  • 4

    In iRBD, NbM volume is linked to reduced risk of phenoconversion to PD or dementia, despite less pronounced clinical correlations.

  • 5

    Identifying NbM volume deficits may aid in predicting cognitive decline and disease progression in early PD and prodromal stages.

Original Source(s)

Cholinergic degeneration in prodromal and early Parkinson’s disease: a link to present and future disease states

  • by Tamir Eisenstein, Karolien Groenewald, Ludo van Hillegondsberg, Falah Al Hajraf, Tanja Zerenner, Michael A Lawton, Yoav Ben-Shlomo, Ludovica Griffanti, Michele T Hu, Johannes C Klein

  • May 6, 2025

Related Content

Influence of Genetic Predisposition and Environmental Factors on Dementia with Lewy Bodies: Intersecting Pathogenic Mechanisms

A homozygous missense variant, p.Ser166Leu in the PRPF40B gene, in a 7.7 Mb region of homozygosity in a consanguineous Turkish family with essential tremor

Acupuncture effects on non-motor symptoms of Parkinson’s disease (sleep, mood, and fatigue): a systematic review and meta-analysis