Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease - Takeaways - MDSpire

Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease

  • By

  • Erica Buoso

  • Mirco Masi

  • Roberta Valeria Limosani

  • Francesca Fagiani

  • Chiara Oliviero

  • Giorgia Colombo

  • Luigi Cari

  • Marco Gentili

  • Eleonora Lusenti

  • Lucrezia Rosati

  • Federica Pisati

  • Alessandra Pasini

  • Marco Vincenzo Lenti

  • Antonio Di Sabatino

  • Claire Louise Mobbs

  • Stefan Przyborski

  • Simona Ronchetti

  • Cristina Travelli

  • Marco Racchi

  • December 18, 2024

  • 0 min

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  • 1

    RACK1 expression is significantly decreased in inflammatory bowel disease (IBD), particularly in ulcerative colitis.

  • 2

    GILZ positively correlates with RACK1 expression, and its depletion leads to impaired epithelial barrier integrity.

  • 3

    The RACK1/SRC/E-cadherin regulatory mechanism is altered in IBD, contributing to epithelial barrier disruption.

  • 4

    Dexamethasone treatment restores RACK1 expression and epithelial barrier integrity in IBD models.

  • 5

    The findings suggest that targeting the GILZ/c-Rel/RACK1 pathway could improve therapies for IBD patients unresponsive to glucocorticoids.

Original Source(s)

Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease

  • by Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Francesca Fagiani, Chiara Oliviero, Giorgia Colombo, Luigi Cari, Marco Gentili, Eleonora Lusenti, Lucrezia Rosati, Federica Pisati, Alessandra Pasini, Marco Vincenzo Lenti, Antonio Di Sabatino, Claire Louise Mobbs, Stefan Przyborski, Simona Ronchetti, Cristina Travelli, Marco Racchi

  • December 18, 2024

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