IFNγ-producing iNKTs restrict a live-attenuated chlamydia oral vaccine in the large intestine - Takeaways - MDSpire

IFNγ-producing iNKTs restrict a live-attenuated chlamydia oral vaccine in the large intestine

  • By

  • Ahmed Mohamed Abdelsalam

  • Yi Wu

  • Mitchell Kronenberg

  • Huizhou Fan

  • Guangming Zhong

  • June 1, 2026

  • 0 min

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  • 1

    Chlamydia muridarum can persist in the large intestine, while the live-attenuated chlamydia oral vaccine intrOv does not.

  • 2

    Invariant natural killer T cells (iNKTs) producing IFNγ are essential for preventing the persistence of the intrOv vaccine.

  • 3

    Mice deficient in lymphocytes but competent in innate lymphoid cells (ILCs) allowed intrOv to persist, highlighting lymphocytes' critical role.

  • 4

    IFNγ+ILC3s block intrOv shedding, while IFNγ+iNKTs prevent its persistence, indicating a division of labor in immune response.

  • 5

    The study provides insights into improving the safety and efficacy of intrOv as an oral vaccine against chlamydial infections.

Original Source(s)

IFNγ-producing iNKTs restrict a live-attenuated chlamydia oral vaccine in the large intestine

  • by Ahmed Mohamed Abdelsalam, Yi Wu, Mitchell Kronenberg, Huizhou Fan, Guangming Zhong

  • June 1, 2026

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