Polymorphic ventricular tachycardia with mutation in KCNJ2: case report - Takeaways - MDSpire

Polymorphic ventricular tachycardia with mutation in KCNJ2: case report

  • By

  • Cuizhen Zhou

  • Juan Chen

  • Cuilan Hou

  • Tingting Xiao

  • Li Zhang

  • June 16, 2026

  • 0 min

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  • 1

    Polymorphic ventricular tachycardia (VT) can arise from genetic mutations, particularly in cardiac ion channels like KCNJ2.

  • 2

    The first patient, a 13-year-old girl, had a de novo KCNJ2 mutation and experienced persistent VT despite multiple treatments.

  • 3

    The second patient, a 5-year-old boy, also had a de novo KCNJ2 mutation and showed significant improvement with flecainide therapy.

  • 4

    KCNJ2 mutations are associated with a benign clinical course, but identifying high-risk mutation carriers remains difficult.

  • 5

    Antiarrhythmic drugs generally have poor efficacy for KCNJ2-related arrhythmias, although flecainide may offer a promising alternative.

Original Source(s)

Polymorphic ventricular tachycardia with mutation in KCNJ2: case report

  • by Cuizhen Zhou, Juan Chen, Cuilan Hou, Tingting Xiao, Li Zhang

  • June 16, 2026

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