Case Report: Rare collision tumors: ACTH-secreting pituitary neuroendocrine tumor and pituicytoma – histopathological and ultrastructural analysis - Takeaways - MDSpire

Case Report: Rare collision tumors: ACTH-secreting pituitary neuroendocrine tumor and pituicytoma – histopathological and ultrastructural analysis

  • By

  • Silvia Carolina Fernández

  • María Celina Bernhardt

  • Ezequiel Grondona

  • Carolina Leimgruber

  • Virginia Juárez

  • Ana Clara Venier

  • María Lorena Bertolino

  • Emilio Mezzano

  • Jorge Humberto Mukdsi

  • Favio Nicolás Pesaola

  • Ana Lucía De Paul

  • April 2, 2026

  • 0 min

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  • 1

    Collision tumors are rare, defined by the coexistence of distinct neoplasms without histological admixture.

  • 2

    This case study details a 21-year-old woman with an ACTH-secreting PitNET and a pituicytoma in the sellar region.

  • 3

    Histopathological analysis confirmed the presence of both tumor types, with specific immunostaining patterns for ACTH and TTF-1.

  • 4

    Post-surgery, the patient developed diabetes insipidus but remained in clinical remission with no residual tumor at nine months.

  • 5

    The report emphasizes the rarity of sellar collision tumors and the need for improved diagnostic strategies.

Original Source(s)

Case Report: Rare collision tumors: ACTH-secreting pituitary neuroendocrine tumor and pituicytoma – histopathological and ultrastructural analysis

  • by Silvia Carolina Fernández, María Celina Bernhardt, Ezequiel Grondona, Carolina Leimgruber, Virginia Juárez, Ana Clara Venier, María Lorena Bertolino, Emilio Mezzano, Jorge Humberto Mukdsi, Favio Nicolás Pesaola, Ana Lucía De Paul

  • April 2, 2026

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