Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation - Takeaways - MDSpire

Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation

  • By

  • Ruofan He

  • Qingqing Xing

  • Songyi Liu

  • Shiwei Lin

  • Xiang Lin

  • Jianxin Ye

  • May 22, 2026

  • 0 min

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  • 1

    RRN3 is a nucleolar protein essential for ribosome biogenesis, with its role in cancer, particularly gastric cancer, being insufficiently defined.

  • 2

    Pan-cancer analysis revealed that RRN3 is upregulated in various tumor types, including gastric cancer, correlating with poor overall survival.

  • 3

    In gastric cancer, RRN3 expression is linked to RNA methylation regulators, immune checkpoint genes, and tumor mutation burden.

  • 4

    Functional experiments demonstrated that RRN3 knockdown inhibited gastric cancer cell proliferation and invasion, while re-expression partially reversed these effects.

  • 5

    Clinical validation confirmed RRN3 upregulation in gastric cancer tissues, associated with several features related to tumor progression.

Original Source(s)

Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation

  • by Ruofan He, Qingqing Xing, Songyi Liu, Shiwei Lin, Xiang Lin, Jianxin Ye

  • May 22, 2026

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