Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study

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A retrospective study of 117 people living with HIV found that 47.9% exhibited abnormal high cortisol levels.
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Group A, with hypocortisolemia, showed higher diastolic blood pressure and longer HIV diagnosis duration compared to Group C.
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The NRTIs + PIs regimen was associated with a significantly higher likelihood of reduced cortisol levels compared to NRTIs + NNRTIs.
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Logistic regression indicated that longer duration of HIV diagnosis and ART regimen type were independently associated with cortisol changes.
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The study highlights the need for understanding cortisol abnormalities in PLWH to inform clinical management and treatment strategies.

Frontiers In Endocrinology

by Han Yajuan, Chen Xingxing, Jiang Huirong, Wan Jinshu, Zhang Yinhua, Pan Xiuzhen, Muhammad Tahir Khan, Xu Chao, Lin Sizhe, Pan Chih-Lin, Liu Yanrong, He Piao
June 26, 2026

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