Multimodal Imaging Analysis of Retinal and Microvascular Changes in Alport Syndrome - Takeaways - MDSpire

Multimodal Imaging Analysis of Retinal and Microvascular Changes in Alport Syndrome

  • By

  • Irem Kirci Dogan

  • Caner Incekas

  • Imren Akkoyun

  • Sezin Akca Bayar

  • Gursel Yilmaz

  • January 19, 2026

  • 0 min

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  • 1

    Alport syndrome is a genetic disorder caused by mutations in COL4A3, COL4A4, or COL4A5, with varying prevalence rates.

  • 2

    Ocular manifestations of Alport syndrome include anterior lenticonus, retinal changes, and structural alterations in the internal limiting membrane.

  • 3

    Recent studies suggest that Alport syndrome leads to broader retinal alterations beyond inner retinal thinning.

  • 4

    Microvascular changes in Alport syndrome include reduced foveal avascular zone area and decreased vascular density.

  • 5

    This study utilized spectral-domain OCT and OCT angiography to evaluate retinal changes in patients with Alport syndrome.

Original Source(s)

Multimodal Imaging Analysis of Retinal and Microvascular Changes in Alport Syndrome

  • by Irem Kirci Dogan, Caner Incekas, Imren Akkoyun, Sezin Akca Bayar, Gursel Yilmaz

  • January 19, 2026

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