Differences in cortisol levels between preterm and term infants: a systematic review and meta-analysis combined with Mendelian randomization study - Takeaways - MDSpire

Differences in cortisol levels between preterm and term infants: a systematic review and meta-analysis combined with Mendelian randomization study

  • By

  • Yun Li

  • Xiaohui Liang

  • Limin Cao

  • Yujing Yang

  • Shujing Wei

  • Yong Ji

  • June 2, 2026

  • 0 min

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  • 1

    Preterm infants exhibit lower cortisol levels in umbilical cord blood and peripheral blood on the first day after birth compared to term infants.

  • 2

    Cortisol levels in preterm infants increase after two weeks, eventually becoming comparable to those of term infants.

  • 3

    Salivary cortisol levels do not differ significantly between preterm and term infants.

  • 4

    Mendelian randomization analysis indicates a negative causal association between preterm birth and cortisone levels.

  • 5

    The study emphasizes the need for high-quality clinical research to validate and optimize glucocorticoid protocols for preterm infants.

Original Source(s)

Differences in cortisol levels between preterm and term infants: a systematic review and meta-analysis combined with Mendelian randomization study

  • by Yun Li, Xiaohui Liang, Limin Cao, Yujing Yang, Shujing Wei, Yong Ji

  • June 2, 2026

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