Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients - Takeaways - MDSpire
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Intensive Care Infection Score Detects Infection in Critically Ill Patients More Effectively Than Inflammatory Biomarkers

  • By

  • Noelle Nacke

  • Christian Hönemann

  • Bastian Blömer

  • Stefanie Klatte

  • Alexander Zarbock

  • Jens-Christian Schewe

  • Marie-Luise Rübsam

  • October 7, 2026

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  • 1

    The study compared the Intensive Care Infection Score (ICIS) with C-reactive protein, procalcitonin, and white blood cell count in critically ill adults.

  • 2

    ICIS combines blood-cell parameters reflecting innate and adaptive immune responses, ranges from 0 to 20, and higher scores indicate a greater probability of infection.

  • 3

    The cohort included adults admitted to a German secondary-care hospital ICU from 2021 through 2023.

  • 4

    Four independent, blinded, board-certified anesthesiologists adjudicated infection status using clinical, laboratory, and microbiological information.

  • 5

    The reference standard classified each patient-day as infection, infection likely, infection unlikely, or no infection; discordant cases without consensus were excluded.

Original Source(s)

Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients

  • by Noelle Nacke, Christian Hönemann, Bastian Blömer, Stefanie Klatte, Alexander Zarbock, Jens-Christian Schewe, Marie-Luise Rübsam

  • October 7, 2026

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