Untargeted metabolomic profiling of hydrosalpinx fluid: a descriptive analysis with pelvic fluid as external reference - Takeaways - MDSpire

Untargeted metabolomic profiling of hydrosalpinx fluid: a descriptive analysis with pelvic fluid as external reference

  • By

  • Haofei Shen

  • Wankun Hao

  • Jianxiu Zheng

  • Xiaorong Luo

  • Chunjie Zhang

  • Ahui Liu

  • Xiaoling Ma

  • Yuan Ding

  • July 3, 2026

  • 0 min

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  • 1

    Hydrosalpinx is a significant cause of infertility, impacting embryo implantation and development due to fluid accumulation.

  • 2

    The study identified 660 metabolites in hydrosalpinx fluid, with 209 upregulated and 451 downregulated compared to normal pelvic fluid.

  • 3

    Key metabolic pathways affected in hydrosalpinx include unsaturated fatty acid biosynthesis, arachidonic acid metabolism, and tryptophan metabolism.

  • 4

    Weighted gene co-expression network analysis revealed core metabolites associated with hydrosalpinx, such as 5-[1-Carboxy-2-(Trimethylazaniumyl) Ethoxy]-5-Oxopentanoate.

  • 5

    The metabolic profile of hydrosalpinx fluid differs significantly from pelvic fluid, indicating alterations in lipid and amino acid metabolism.

Original Source(s)

Untargeted metabolomic profiling of hydrosalpinx fluid: a descriptive analysis with pelvic fluid as external reference

  • by Haofei Shen, Wankun Hao, Jianxiu Zheng, Xiaorong Luo, Chunjie Zhang, Ahui Liu, Xiaoling Ma, Yuan Ding

  • July 3, 2026

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