Lower odds of prevalent vertebral fractures with b/tsDMARD use among rheumatoid arthritis patients in clinical remission: a retrospective observational study - Takeaways - MDSpire
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Reduced prevalence of vertebral fractures in rheumatoid arthritis patients in clinical remission using b/tsDMARDs: a retrospective observational analysis

  • By

  • Yu Yamashita

  • Kazuhiro Maeda

  • Asami Zenitani

  • Mitsuru Saito

  • May 13, 2026

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  • 1

    Rheumatoid arthritis (RA) leads to systemic bone loss and increased fracture risk, particularly in the vertebrae and proximal femur.

  • 2

    The study focused on patients with RA in clinical remission to assess the impact of b/tsDMARDs on vertebral fractures and serum pentosidine levels.

  • 3

    A total of 76 patients were included, with vertebral fracture assessments conducted on 51 patients using thoracolumbar spine radiographs.

  • 4

    Elevated serum pentosidine levels, indicating poor bone quality, are linked to a higher risk of fragility fractures in RA patients.

  • 5

    The findings suggest that b/tsDMARD use may be associated with a reduced prevalence of vertebral fractures in RA patients in remission.

Original Source(s)

Lower odds of prevalent vertebral fractures with b/tsDMARD use among rheumatoid arthritis patients in clinical remission: a retrospective observational study

  • by Yu Yamashita, Kazuhiro Maeda, Asami Zenitani, Mitsuru Saito

  • May 13, 2026

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