Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports - Takeaways - MDSpire

An Overview of Anesthetic Complications Associated with Genetic Mitochondrial Disorders: Insights from Case Reports

  • By

  • Brittany M. Johnson

  • Simon C. Johnson

  • July 7, 2026

Share

  • 1

    Genetic mitochondrial diseases (GMDs) affect approximately 1 in 4000 individuals and are caused by defects in mitochondrial genes.

  • 2

    GMDs exhibit significant genetic and clinical heterogeneity, with over 400 unique genetic alterations linked to various syndromes.

  • 3

    Patients with GMDs may experience hypersensitivity to general anesthesia, particularly to volatile anesthetic agents.

  • 4

    Anesthetic exposure in GMD patients can lead to complications ranging from mild metabolic changes to severe outcomes, including death.

  • 5

    A review of case reports highlights the need for further investigation into the anesthetic complications associated with GMDs.

Original Source(s)

Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports

  • by Brittany M. Johnson, Simon C. Johnson

  • July 7, 2026

Related Content

Three-dimensional reconstruction by a computer-assisted surgery system for pediatric hydronephrosis caused by accessory renal artery compression: a single-center retrospective observational comparative case series

Pigtail catheter found in the Lingula of a pediatric patient on VV-ECMO while performing flexible bronchoscopy: a case report on an unexpected finding

Pneumovesicoscopic ureteral reimplantation for pediatric vesicoureteral reflux: Politano-Leadbetter vs. Cohen technique