The predictive value of prognostic immune and nutritional index in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy: a retrospective propensity score matching study - Takeaways - MDSpire

The predictive value of prognostic immune and nutritional index in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy: a retrospective propensity score matching study

  • By

  • Xiao Wu

  • Liang Wang

  • Xun Yang

  • Qixun Chen

  • Jifeng Feng

  • May 21, 2026

  • 0 min

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  • 1

    The prognostic immune and nutritional index (PINI) is a significant predictor of clinical outcomes in esophageal squamous cell carcinoma (ESCC) patients.

  • 2

    A study of 193 ESCC patients undergoing neoadjuvant immunochemotherapy established a PINI cutoff of 3.320 to differentiate survival outcomes.

  • 3

    Patients with low PINI showed significantly worse disease-free survival (DFS) and overall survival (OS) compared to those with high PINI.

  • 4

    Multivariate analysis confirmed PINI as an independent prognostic index for DFS and OS in the pre-matched cohort of ESCC patients.

  • 5

    Incorporating PINI into existing prognostic models may enhance long-term risk stratification and personalize treatment strategies for ESCC.

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