Clinical implications of HLA-B*15:02 screening in pediatric patients: A case series from a Thai Binh Children's Hospital, Vietnam

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Carbamazepine is linked to severe cutaneous adverse reactions, notably Stevens-Johnson syndrome and toxic epidermal necrolysis.
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HLA-B*15:02 is a genetic marker associated with carbamazepine-induced SJS/TEN, particularly in Southeast Asian populations.
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In a study of 14 pediatric patients, 21.4% tested positive for HLA-B*15:02, prompting changes in their treatment plans.
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No severe adverse reactions were reported during the follow-up period for patients who underwent HLA-B*15:02 screening.
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The study suggests that HLA-B*15:02 screening is feasible in provincial hospitals and may enhance the safety of carbamazepine prescribing.

Frontiers In Pediatrics

by Pham Thi, Huong , Tran Trong, Kiem , Do Manh, Dung , Luu Thi, Hoa , Doan Thi Ngoc, Hoa , Le Thi, Ha , Truong Thi Phuong, Mai
April 15, 2026

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