Increased lymphoma risk in patients with systemic manifestations of Sjögren’s disease: a population-based study

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The study analyzed 278 patients with primary Sjögren’s disease, classifying them into glandular and systemic phenotypes.
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Systemic phenotype patients exhibited higher disease activity, with ESSDAI scores significantly greater than those with glandular phenotype.
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Lymphoma developed in 15 patients, with a higher occurrence in the systemic phenotype group compared to the glandular group.
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Sicca symptoms were prevalent in both phenotypes, with xerophthalmia and xerostomia reported in 89% and 84% of patients, respectively.
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Immunosuppressive therapy was more frequently utilized in patients with systemic involvement of primary Sjögren’s disease.

Frontiers In Medicine

by Teresa Blázquez-Sánchez, Arantxa Torres-Roselló, Javier Llorca, Jorge Mairal-Monesma, Otto Olivas-Vergara, Raquel Largo, Esperanza Naredo, Miguel Ángel González-Gay
May 29, 2026

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