Influenza Vaccine Dose and Dementia Outcomes
US claims data compare high- vs standard-dose formulations in patients aged 65 years or more over 3 years of follow-up
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By
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Kathryn Wighton
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April 10, 2026
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1
High-dose influenza vaccine recipients aged 65 and older had a lower risk of incident Alzheimer dementia compared to standard-dose recipients.
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The study analyzed data from 185,183 high-dose and 53,918 standard-dose person-trials without prior cognitive impairment.
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High-dose vaccination showed a maximum absolute risk difference of approximately 0.5%, with a number needed to treat of 185 at month 25.
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Sustained seasonal high-dose vaccination was linked to lower Alzheimer dementia risk, particularly notable at month 27.
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Limitations included a follow-up of only 3 years and potential misclassification in claims-based data affecting results.
