Response to Concerns Regarding Intensive Chemoprophylaxis During Influenza Outbreaks in Nursing Homes

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Oseltamivir chemoprophylaxis was assessed using electronic medication administration record (eMAR) data from nursing home staff.
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The study found that substantial unmeasured oseltamivir use in the nonintensive group is unlikely due to controlled medication administration.
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Censoring after the 2-day grace period led to a substantial reduction in the intensive-strategy risk set due to noncompliance.
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Inverse-probability-of-censoring weighting was used to address potential selection bias from the uncommon intensive chemoprophylaxis strategy.
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The authors encourage replication of their study using eMAR data to support findings on oseltamivir chemoprophylaxis during influenza outbreaks.

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